Biophilia Tracker for Celiac Disease Diagnosis
Intrahepatic cholangiocarcinoma is diagnosed in 7-35% of all cases of malignant liver tumors. Early detection of this pathology is one of the most difficult tasks in hepatology diagnosis, since tumors often develop in the context of chronic diseases of the liver and bile excretion ducts and are masked by the symptoms of these diseases.
Testing for cholangiocarcinoma has periodically increased in recent years. It is explained by the introduction of modern visualization methods, which allow a more accurate specification of the localization and prevalence of tumor processes. The peak incidence is between the ages of 50 and 70. The disease occurs almost equally in men and women.
The main accompanying syndromes of this disease are obstructive jaundice and cholestasis, which greatly reduce the regenerative ability of the parenchyma. Suppurative cholangitis develops in the late stages of the disease and is sometimes the cause of death in the patient.
Cholangiocarcinoma has a glandular structure, originates from the intrahepatic bile duct epithelium, and contains keratin, which explains its density. Tumors may develop at any level of the biliary tree and spread to the liver. Because the tumor is characterized by slow infiltrative growth within or along the vessel wall, it does not form a clearly visible volume of tumor and does not have clear borders. When the tumor compresses the bile duct, bile hypertension of varying intensity and dilatation of the overlying portion of the biliary tract occurs (depending on tumor spread). Below the point of obstruction, the common bile diameter and gallbladder size decrease.
Analysis of clinical symptoms and biochemical indicators alone does not always reveal the cause of cholestasis, especially in patients with relatively short and low hyperbilirubinemia. It is also important to note that most patients with this disease are elderly and have already developed complications and are admitted to the surgical department of the hospital.
The only effective treatment for cholangiocarcinoma is surgical intervention, which emphasizes the importance of prompt examination to detect "smaller" tumors. The 5-year survival rate for patients with small tumors is 85%. The main factor that determines tumor resectability is the functional potential of the remaining portion of the liver.
The most important methods for the preliminary diagnosis of biliary excretion dust pathology are non-invasive investigation methods (ultrasound scan, computed tomography and magnetic resonance imaging). However, these methods cannot clearly detect the localization of the focal process and its characteristics. Based on the data obtained, the therapist decides on more accurate invasive diagnostic methods: endoscopic retrograde cholangiopancreatography (ERCPG), percutaneous transhepatic cholangiography (PTCG), and in some cases - angiographic studies and liver biopsy. The choice of method depends on its availability, information value, safety and affordability.
The recent emergence of nonlinear diagnostic (NLS) methods may now be the most available method for the initial diagnosis of celiac disease. One of the most promising trends in NLS diagnostics proposed by Biophilia Tracker is three-dimensional NLS imaging, which has certain technical and practical advantages in the visualization of anatomical and pathological structures compared with other hardware visualization methods. The computer-processed data can be processed and the three-dimensional model transverse planes can be adjusted so that images of organs in various projections can be studied.