Biophilia tracker X3 helps and develops clinical medicine
Some examination data were studied for patients with a bone marrow transplant and clinical symptoms of fever of obscure genesis. The authors demonstrated high reliability of the Biophilia Tracker X3 NLS in determining fungal infection in 20 of 24 cases. Besides, the fact that no changes were detected during NLS lung examination allows to assume that the fever was caused by bacterial or fungal infection of extra pulmonary genesis.
It is also a proven fact that the sensitivity with NLS is higher than with standard computer tomography. We examined 150 patients. Using conventional CT (10 mm collimation) and NLS, we found that NLS had a higher sensitivity in recognizing pathological changes in the lung tissue.
Due to its high sensitivity, NLS should be used to define lung diseases in patients with a normal or obscure aspect of disease who have a pulmonary disturbance or symptoms that suggest an acute or chronic diffuse lung disease.
Even with certain clinical signs in evidence, the diagnostic accuracy of classic radiography in patients affected by DILD appears to be limited. The reason is both superposition of the image in the radiograph and low contrast of minute lung structures. NLS is free of these aspects, which is why it is reputed to be a more efficient method for recognizing diffuse lesions of lung tissue as compared to both radiographic survey and conventional computer tomography.
Besides, having a higher sensitivity, specificity and diagnostic accuracy, the Biophilia Tracker X3 NLS method can become a determining factor in evaluating the activity of a pathological process in patients affected by DILD. In certain cases NLS can be used not only to define the presence or absence of a pathological process or the extent to which it has spread, but also to collect information about the reversibility of changes (in an acute or active phase) as compared to irreversible (fibrotic) changes in the lung tissue. Moreover, since NLS can accurately identify the imponderable activity of a pathological process in the lungs, it can be employed to evaluate the efficiently of the treatment given to the patients.
The conventional methods for evaluating disease activity, such as transbronchial lung biopsy (TBLB), bronchoalveolar lavage (BAL), chest radiography, gallium lung scanning and functional lung tests are insufficiently reliable in evaluating the activity and in terms of prognostication. So the open lung biopsy (OLB) is still the choice method for both diagnosing and evaluating the process activity. We were able to prove, that signs detected in patients by means of NLS can provide some valuable information and be significantly important in defining the activity of a pathological process.
In terms of its prognostic value Biophilia Tracker X3 NLS is now advancing to the foreground leaving behind some functional lung tests, BAL and even OLB, because it allows to assess a lesion of actually the whole lung parenchyma as compared to a separate biopsy sample. Moreover, NLS can become an accurate noninvasive method for evaluating the efficiency of the administered treatment.
Sarcoidosis is one of the most common interstitial lung diseases of unknown etiology. In typical cases, granulomas are formed in fine lymph vessels or beside them, afterwards the granulomas self-organize that causes lung tissue fibrosis. A number of researchers considered the Biophilia Tracker X3 NLS potentials in defining the process activity in patients affected by sarcoidosis. The main activity indicator is the presence of small nodules and to a lesser degree their distribution and occurence in the lung tissue. Unfortunately, despite the difference between reversible and irreversible changes detected by NLS for patients having sarcoidosis, the potentials of NLS in assessing the process activity have not been studied well enough.